A pharmacological study of chlorphenesin carbamate. Tolerance to chlorphenesin carbamate
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چکیده
منابع مشابه
The action of chlorphenesin carbamate on the frog spinal cord.
Studies were carried out to elucidate the mechanism of action of chlorphenesin carbamate (CPC) and to compare the effect of the drug with that of mephenesin on the isolated bullfrog spinal cord. Ventral and dorsal root potentials were recorded by means of the sucrose-gap method. CPC caused marked hyperpolarizations and depressed spontaneous activities in both of the primary afferent terminals (...
متن کاملEffect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats.
The effects of chlorphenesin carbamate (CPC) and mephenesin on spinal neurons were investigated in spinal rats. CPC (50 mg/kg i.v.) inhibited the mono-(MSR) and poly-synaptic reflex (PSR), the latter being more susceptible than the former to CPC depression. Mephenesin also inhibited MSR and PSR, though the effects were short in duration. CPC had no effect on the dorsal root potential evoked by ...
متن کاملChlorphenesin: an antigen-associated immunosuppressant.
Chlorphenesin (3-p-chlorophenoxy-1,2-propanediol), when injected intravenously together with either of two common bacterial antigens, inhibits the antibody response of the rabbit. The antigens studied are those common to Enterobacteriaceae and to gram-positive bacteria. The immunosuppression is contingent upon incubation of chlorphenesin and antigen in vitro prior to administration, since separ...
متن کاملStabilizing guanosine-sterol ion channels with a carbamate to urea modification in the linker.
The use of a bis-urea lithocholamide linker within a guanosine-sterol dimer resulted in formation of large and stable ion channels. The channels were longer-lived than those formed by the corresponding bis-carbamate.
متن کاملEffect of chlorphenesin on localized hemolysis in gel assay.
Chlorphenesin, a simple glycerol ether, when added to Jerne plates greatly reduced the number of hemolytic plaques. This effect appeared to be related to dose, and was clearly demonstrable with antibody-forming spleen cells from mice that had been immunized either with sheep red blood cells or with penicillin G conjugated with Keyhole limpet hemocyanin. Chlorphenesin did not affect the antigen,...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1977
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.73.347